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Genomics and Health Impact Blog Posts

Tracking Translation of Human Genome Discoveries into Prevention and Control of Common Chronic Diseases: The Action is in Cancer!

cancer cells with DNA and a few people in the foreground

Genomics seems to be everywhere these days. From the Human Genome Project to the Precision Medicine Initiative and from the Cancer Moonshot to breakthroughs in genome editing, we are overwhelmed with information about genomics. The hope and hype of discoveries are intermixed daily in published scientific articles and media coverage of how they might improve Read More >

Posted on by Muin J. Khoury MD, PhD, Director, Office of Public Health Genomics, and Lisa Richardson, Director, Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment

What Gets Measured Gets Done: Public Health Progress in Familial Hypercholesterolemia

a heart with a graph and people in the foreground

Just 4 years ago, one of us (MJK) co-chaired the Familial Hypercholesterolemia (FH) Foundation’s first FH Global Summit: Awareness to Action held in Annapolis, Maryland. The Summit brought together people from academia, government, the private sector, clinicians, as well as patients with the ambitious goals of raising awareness of FH, identifying key knowledge gaps, and Read More >

Posted on by Joshua Knowles MD, guest blogger, Stanford University School of Medicine and Muin J. Khoury MD, PhD, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia1 CommentTags

The Cancer Moonshot, Hereditary Cancers and Population Genetic Screening

Cancer Moonshot with an image of a moon surrounded by DNA and a crowd of people

In September 2016, the Cancer Moonshot Blue Ribbon Panel delivered a report with 10 ambitious recommendations to shape cancer research for the next five years. One recommendation is to “expand use of proven prevention and early detection strategies.” [PDF 199 KB] There is a lot we can do to prevent cancer now— even with no Read More >

Posted on by Muin J. Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention, and Lisa C. Richardson, Director, Division of Cancer Prevention and Control, Atlanta, GeorgiaLeave a comment

Precision Public Health: More Precision Ahead for Individual and Population Interventions

people holding a sign reading Medicine & Public Health with DNA

In August 2016, we published a point-counterpoint viewpoint asking a crucial question that has been on the minds of researchers, health care providers and the public health community: “will precision medicine improve population health?” We understood that we were tackling “the elephant in the room” and hoped for reactions to this viewpoint. We were pleased Read More >

Posted on by Muin J. Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, and Sandro Galea, Dean, School of Public Health, Boston University, Boston, Massachusetts2 CommentsTags ,

Precision Medicine and Population Health: Dealing With the Elephant in the Room

In this week’s Journal of American Medical Association, we published a point-counterpoint commentary on the impact of precision medicine on population health. Announcement of the news of the US precision medicine initiative has been met with a range of responses from enthusiasm to skepticism about potential benefits, limitations and return on investment. In considering the Read More >

Posted on by Muin J. Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, and Sandro Galea, Dean, School of Public Health, Boston University, Boston, Massachusetts1 CommentTags

Five Misconceptions About the Role of Genomics in Public Health

5 Misconceptions arrow pointing to 5 and Facts arrow pointing to a hand holding a double helix with a crowd in the background

In a recent post, I reviewed the progress of genomics in public health over the past two decades and pondered on the lingering skepticism about genomics in the public health community. I propose that this skepticism is driven, at least in part, by 5 common misconceptions about the role of genomics in public health. In Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 Comment

From Genes to Public Health 1996-2016: The Train Has Left the Station

train leaving the station with DNA

In 1996, a working group from the Centers for Disease Control and Prevention published an article in the American Journal of Public Health entitled: “From Genes to Public Health: Applications of Genetic Technology in Disease Prevention.” The agency-wide group assessed the implications of the Human Genome Project and related technologies for public health and disease Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags

Precision Public Health: Reconciling Biological and Social Determinants of Health

a mother and child surrounded by DNA and several images of environmental factors

On June 6-7, 2016, I had the honor of participating in the “Precision Public Health” summit hosted by the Gates Foundation and the White House Office of Science and Technology at the University of California in San Francisco. The summit focused on developing a global “precision” agenda to improve health and prevent death and disease Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 CommentTags

The Shift From Personalized Medicine to Precision Medicine and Precision Public Health: Words Matter!

crowd with on figure standing out and DNA on the top

Advances in genomics and other ‘omic’ technologies have ushered in a new era variably called “personalized” or “precision” medicine, which takes into account individual genetic and other sources of variability in disease treatment and prevention. In the past decade, we have seen a significant growth in interest and usage of the terms personalized and precision Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 Comment

Does genetic risk information improve healthy behavior? Let’s not throw out the baby with the bath water!

a double helix in a green circle, a glass of alcohol in a red circle wth a slash through it, a No Smoking stop sign, excercise equipement, an apple and a Screening door tag

In a recent systematic review with meta-analysis, Hollands et al evaluated the impact of communicating genetic risk information on risk-reducing health behaviors and motivations for behavior change. The authors reviewed 18 studies with 7 behavioral outcomes, including smoking cessation, diet and physical activity. They found no significant effects of communicating DNA based risk estimates on Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags ,
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