Genomics and Precision Health Posts

Accelerating Precision in Public Health Surveillance and Response

When our communities face a health crisis, the research, clinical, and public health worlds come together and collaborate. Public health programs drive toward prevention, diagnosis, and treatment of the population, but they need the support and guidance of data-driven research behind them every step of the way. While most of the data needed to accelerate Read More >

Posted on by Paula Braun (CDC), Kevin Chaney (ONC), Muin J. Khoury (CDC), Teresa Zayas Cabán (ONC)Leave a commentTags

Genetic Counseling in the Time of COVID-19

a hand magnifying DNA on COVID-19 with cellphones, tablets and laptops being connected by figures

Genetic counselors play an important role in clinical genetics by helping patients understand their genetic health risks. Due to the COVID-19 pandemic, most clinics and hospitals have restricted in-person delivery of non-essential healthcare services, including genetic counseling, to slow the spread of the virus. However, delaying genetic counseling can be problematic, for example, when genetic Read More >

Posted on by Katie Bruder, Genetic Counseling Training Program Class of 2020, Emory University School of Medicine and Ridgely Fisk Green, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Implementation Science to Improve Case Finding, Cascade Screening, and Treatment for Familial Hypercholesterolemia: A Prototype for Precision Public Health Research

a heart being magnified in a body, a FH pedrigree on top of a US map and a heart being listened to wiht a stethoscope

Familial Hypercholesterolemia (FH) is a common genetic disorder, affecting more than 1 million people in the United States. FH causes lifelong high levels of low-density lipoprotein cholesterol, and if untreated, leads to a high risk of premature coronary heart disease. Most patients with FH are undiagnosed or inadequately treated with regular or high-intensity statins, leaving Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, Georgia and George A Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, Bethesda, MarylandLeave a commentTags

How Can Evidence Synthesis be Conducted at the Speed of a Pandemic?

COVID-19 and a person dealing with data

Since December, 2019, SARS-CoV-2, the virus that causes COVID-19, has rapidly spread around the world. The global pandemic has led to numerous scientific publications in basic, clinical and public health science and increased pressure to act on evidence as it emerges. Typically, research is done to inform decisions over time and is disseminated to the Read More >

Posted on by Caitlin G. Allen, W. David Dotson, Scott Bowen, Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

The Public Health Impact of COVID-19: Why Host Genomics?

covid-19 virus overlayed on whole genome sequencing with a world map in the background where figures are connected with lines

Throughout human history, zoonotic pandemics have periodically resulted in catastrophic human morbidity and mortality exceeding war, famine, and natural disasters combined. Modern era medicine and public health have made remarkable advances, but vulnerabilities have also increased with unprecedented world population growth, greater interaction with wildlife, and the dramatic expansion of international air travel. Viral diseases Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention, Atlanta, Georgia; Marta Gwinn, CFOL International for Office of Advanced Molecular Detection, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Priya Duggal, Genetic Epidemiology Program, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland1 CommentTags ,

Using Digital Technologies in Precision Public Health: COVID-19 and Beyond

a hand holdign a cell phone with lots of data surrounding it including a coronavirus cell

With the global spread of COVID-19, there is a proliferation of scientific information and publications that use novel approaches such as genomics and precision health tools (e.g., big data, wearables, and digital devices) in surveillance and epidemiologic investigations. Could these new technologies provide added value to traditional approaches? In the past, we have written about Read More >

Posted on by Muin J. Khoury, Scott Bowen, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, Georgia; Paula Braun, Entrepreneur in Residence, Centers for Disease Control and PreventionLeave a commentTags ,

Manipulating the Human Microbiome for Precision Public Health: Prospects and Challenges

a body with different external influences surrounding it

Spotlight on the Human Microbiome The human microbiome has a crucial role in driving public health science and initiatives towards more “precision”. In a recent viewpoint and podcast, Harkins, et al. discuss the potential and current applications for manipulating the human microbiome for disease prevention and management. The authors describe several examples of microbiome manipulation Read More >

Posted on by Melia Haile, Alison Laufer Halpin, Christopher Elkins, and Clifford McDonald, Division of Healthcare Quality Promotion, NCEZID; Muin J. Khoury, Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

In the Era of Public Health Emergencies, Interoperability Rules are a Beacon for More Precision in Public Health

In the current wake of COVID-19, it is evident that the public health ecosystem needs to modernize how we gather, make sense of, and disseminate data from multiple sources.  The health threats we face today spread wider and change faster than the data flows our traditional approaches were designed to accommodate.  Becoming more adept with Read More >

Posted on by Paula Braun, Entrepreneur in Residence, Centers for Disease Control and PreventionLeave a comment

A Public Health Genomics Pioneer

headshot of Toby Citrin

Remembering Toby Citrin Today, public health genomics is an established and respected field which is integrated into numerous public health programs. This was not the case in the year 2000. CDC had established the Office of Genomics and Precision Public Health two years prior (initially called the Office of Genetics and Disease Prevention), but few Read More >

Posted on by Scott Bowen, Muin J Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention with Sharon Kardia and Stephen Modell, University of Michigan1 Comment

Should polygenic risk scores be used in risk-stratified colorectal cancer screening?

a polygenic risk score bell and a body with a colon being exposed

Polygenic risk scores (PRS) summarize information about a person’s disease risk based on numerous DNA variants in their genome. Each variant confers very little increase in disease risk. But composite (or polygenic) risk scores made up of a number of such variants have been shown to stratify people to normal distributions of disease risks for Read More >

Posted on by W. David Dotson, Office of Genomics and Precision Public Health, Office of Science; Nicole F. Dowling, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion; & Muin J. Khoury, Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags