Genomics and Precision Health Posts

The Current Landscape of CDC Publications in Human Genomics and Public Health

sequencing with a double helix and a doctor pointing to different icons above a farm field

In October 2021, the CDC Office of Genomics and Precision Public Health (OGPPH) launched a new, five-year initiative to strengthen public health capacity in genomics and precision medicine. The emergence of evidence-based genomic applications and lack of equity in their implementation in clinical and public health practice provided an important impetus for this initiative. To Read More >

Posted on by Mindy Clyne, W. David Dotson, Anja Wulf, Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment

Genomics and Precision Medicine 2021: Progress in Implementation, A Focus on Health Equity, and a New Public Health Initiative

a doctor using his stethoscope on a puzzle piece of a population with dice changing from 2021 to 2022

In this post, we reflect on another eventful year in genomics and precision medicine and review the emerging opportunities for the field to make an impact on population health. We use the annual review published by the National Human Genome Research Institute (NHGRI) along with our own website updates, and blogs as a springboard for Read More >

Posted on by Muin J. Khoury, Scott Bowen, W. David Dotson, Katherine Kolor, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags , ,

The Use of Machine Learning in Health Care: No Shortcuts on the Long Road to Evidence-based Precision Health

a doctor points to different icons

Two recent systematic reviews reveal the high risk of bias present in randomized controlled trials (RCTs) and observational studies based on machine learning and artificial intelligence. Digitization of health data holds profound potential to change the way we collect information and interact with the health care system. In current times, an increasing volume of health-related Read More >

Posted on by Danielle Rasooly and Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Applications of Polygenic Risk Scores to Population Health: Where Are We?

a polygenic risk curve over a population

An international multidisciplinary group of experts in genetics, law, ethics, behavioral sciences, and other fields reviews the state of science on polygenic scores and highlights risks and gaps before widespread use in practice. Polygenic risk scores (PRS) combine the small effects of many genes across the human genome to estimate the risk of a disease Read More >

Posted on by Muin J. Khoury, W. David Dotson, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Contributions of Genomics to the Fight Against Malaria

This Giemsa-stained, thin film blood smear photomicrograph reveals the presence of a young, growing, Plasmodium vivax trophozoite (Lt), and a platelet stack (Cntr), which resembles a P. falciparum gametocyte.

Malaria was endemic in the United States (US) when the Communicable Disease Center was purposefully opened in Atlanta, GA, rather than Washington DC, in 1946. The Communicable Disease Center, now the US Centers for Disease Control and Prevention (CDC), was started closest to where malaria elimination efforts were needed: the Southern US, including Georgia, suffered Read More >

Posted on by Colleen Scott, Division of Global HIV & TB, and Eldin Talundzic, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

New CDC Partnerships to Advance the Development and Validation of Next Generation Sequencing Tests: A Publicly Available List of Expert Curated Variants

a person using scissors to cut DNA

Over the last decade, genetic testing has evolved from examining a few well-defined variants in one or a few genes to the capability to examine much of the human genome using next generation sequencing (NGS). These analyses are particularly useful for disorders with locus and allelic heterogeneity, and are now the norm in several clinical Read More >

Posted on by Lisa V. Kalman, Ira M. Lubin, Division of Laboratory Systems, Centers for Disease Control and PreventionLeave a commentTags

Happy Thanksgiving 2021: Family Health History in the COVID-19 Era

Knowing and acting on your family health history can protect your health. Use My Family Health Portrait to take the first steps: Collect your family helath history - Share it with your doctor and family; an image of an extended family with a button labeled VISIT My Family Health Portrait

For a second year in a row, this Thanksgiving might not look the same as the ones before it, but some things haven’t changed. Even if you can’t see your loved ones in person, Thanksgiving is still a great time to talk to your family members about your family health history. Having one or more family members Read More >

Posted on by Ridgely Fisk Green and Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and PreventionLeave a comment

The Science of Gene-Environment Interaction at the Centers for Disease Control and Prevention and Agency for Toxic Substances and Disease Registry

a double helix with different viruses and diseases

Now, more than ever, we are aware that our environment has implications for our health. We are also learning more about the effects of inherited traits, such as blood type, on disease susceptibility and progression. Understanding the interactions between our environment and our genes and how they affect health outcomes offers a multitude of potential Read More >

Posted on by Stephanie Foster, Office Of Innovation And Analytics, Agency For Toxic Substances And Disease Registry; Marta Gwinn, Wei Yu, and Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and PreventionLeave a commentTags

An Expanding List of Tier 1 Genomic Applications: Evidence-based Guidelines for Hypertrophic Cardiomyopathy and Public Health

a heart in a body with the text: Tier 1 Genomic Applications

The CDC Tier-Classified Guideline Database includes three Tier 1 guidelines on hypertrophic cardiomyopathy (HCM). A 2014 guideline from the European Society of Cardiology, a 2017 guideline from the American Heart Association, American College of Cardiology, and Heart Rhythm Society, and a 2020 guideline from the American Heart Association and American College of Cardiology all recommend Read More >

Posted on by Michael A. Burke and Laurence S. Sperling, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, W. David Dotson and Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, Georgia1 CommentTags , ,

Large-Scale Population Studies as a Path to Personalized Medicine: Easier Said than Done!

two puzzle pieces coming together made out of a population with a magnifying glass on them and DNA in the background

For more than two decades, advances in genomics have promised a new era of personalized or precision medicine (i.e., the right intervention to the right person at the right time). Scientific evaluation of new gene discoveries has been aided by the launch of large-scale epidemiologic and clinical collaborative global studies. In a recent commentary, McCarthy Read More >

Posted on by Muin J. Khoury and Marta Gwinn, Office of Genomics and Precision Public Health, Centers for Disease Control and PreventionLeave a commentTags