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Category: genomics

Familial Hypercholesterolemia as a Prototype for Precision Public Health

a cross section of an artery with cholesterol buildup

In October 2019, the 7th annual FH Foundation global summit on familial hypercholesterolemia (FH) took place in Atlanta, Georgia. The theme of the conference was, “Familial Hypercholesterolemia as a Prototype for Precision Public Health.” The meeting brought more than 300 participants from multiple countries to discuss the latest advances in the diagnosis, screening, treatment and Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics and Betsy L. Thompson, Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Public Health Perspectives on Ensuring Life Long Benefits of Newborn Screening

a newborns foot

This blog post is a summary of a Perspective recently published in Pediatrics that was authored by Alex Kemper of Nationwide Children’s Hospital, Jeffrey Brosco of the Miller School of Medicine, University of Miami, and Coleen Boyle and Scott Grosse of CDC’s National Center on Birth Defects and Developmental Disabilities. Newborn screening is a highly Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment

Many Adults with Familial Hypercholesterolemia Are Not Meeting Goal LDL-Cholesterol Level

a group of adults and a drop of blood with LDL-C and an up arrow

People with the genetic disorder familial hypercholesterolemia (FH) have increased blood levels of low-density lipoprotein (LDL) cholesterol, which increases their risk for developing coronary artery disease or having a heart attack. A recent study using data from the FH Foundation’s CASCADE FH Registry suggests that many individuals with FH are not meeting blood LDL-cholesterol level Read More >

Posted on by Ridgely Fisk Green, Carter Consulting, Inc. and Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention; Caitlin G. Allen, Behavioral Sciences and Health Education Department, Rollins School of Public Health, Emory University; Quanhe Yang, Epidemiology and Surveillance, Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and PreventionLeave a commentTags ,

What’s the “value” of exome sequencing in children with neurodevelopmental disorders?

children in a classroom setting

This is a summary of a recent commentary in Genetics in Medicine by Grosse and Rasmussen. Exome sequencing (ES) is increasingly used as part of the genetics evaluation of neurodevelopmental disorders, and acute illness in newborns of suspected genetic origin, among others. However, barriers to the clinical use of ES include a widespread reluctance of insurers Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags , ,

Can a Healthy Lifestyle Reduce Your Risk of Dementia Regardless of Your Genes? – Part II

three set of figures depicting dementia

A new, long term cohort study suggests that healthy lifestyle is associated with a lower risk for dementia among people considered at lower and intermediate genetic risk but not for those considered at high genetic risk. “Globally, about 47 million people were living with dementia in 2015, and this number is projected to triple by Read More >

Posted on by Scott Bowen, Office of Public Health Genomics; Christopher Taylor, Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion; and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Can an Aspirin a Day Prevent Colorectal Cancer in People with Lynch Syndrome?

a hand holding a pill with several other pills on the table and a pill bottle and a body with an exposed colon

Encouraging news for group at much greater risk of CRC Lynch syndrome (LS) is the most common cause of hereditary colorectal (colon) cancer (CRC). People with LS have a 50-70% risk of developing CRC in their lifetimes – far higher than the 4% risk within the general population where CRC is a leading cause of Read More >

Posted on by Scott Bowen, Office of Public Health Genomics; Nicole Dowling, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion; and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Introducing the CDC Office of Genomics and Precision Public Health: What’s in a Name?

Public Health Genomics changing to Genomics & Precision Public Health with a checkmark and DNA

Starting this week, the CDC Office of Public Health Genomics will be renamed the CDC Office of Genomics and Precision Public Health. In many ways, this transition has been a few years in the making and reflects the continuous broadening of our scope from human genomics and public health to include other areas relevant to Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment

Data Science and Machine Learning in Public Health: Promises and Challenges

a man holding two circles - one with a bar chart and one with a tablet with data coming out

In August 2019, two of us (CJP, DR) visited the Centers for Disease Control and Prevention and gave a seminar on the promises and challenges of using “big data” for “precision public health” using the tools of “data science”. The seminar was well attended, with more than 200 participants. The audience was engaged, asking great Read More >

Posted on by Chirag J Patel and Danielle Rasooly, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Genetic Counseling and Public Health in the Era of Precision Medicine

In August 2019, the All of Us Research Program announced the funding of a nationwide resource to provide genetic counseling support to one or more million participants in the precision medicine cohort in the United States. Participants from diverse populations will share health information over time through surveys and electronic health records, and they will Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia1 CommentTags , ,

Implementation science and genomic medicine in action: A case study

lab workers and DNA

There is an urgent need for researchers and implementers of genomic medicine to incorporate implementation science into their translational research efforts. Implementation science is the study of methods to promote the adoption and integration of evidence-based practices, interventions, and policies into routine healthcare and public health settings to improve our impact on population health. But Read More >

Posted on by Mindy Clyne, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,
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