Category: genomics

Research on the Behavioral Impact of Polygenic Risk Scores: The Train Has Already Left the Station!

a Polygenic Risk Scores with a train leaving the station

There has been a lot of discussion recently about the new generation of polygenic risk scores (information about a person’s disease risk based on many dozens, hundreds, thousands, or even millions of common DNA variants in their genome), and whether these new-and-improved genetic risk scores are going to turn out to be useful for disease Read More >

Posted on by Saskia Sanderson, Guest Blogger, University College London Institute of Health Informatics, London, United Kingdom and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment
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Introducing the Rare Diseases Genomics and Precision Health Knowledge Base

a black swan in a sea of white swans and DNA

For the past three years, The CDC Public Health Genomics Knowledge Base (PHGKB) has been tracking the public health impact of advances in genomics and precision technologies. Every day, we provide new information and publications for researchers, health care providers, policy makers, and the general public. We also offer access to the latest epidemiologic and Read More >

Posted on by Muin J. Khoury and Wei Yu, Office of Public Health Genomics. Centers for Disease Control and Prevention2 Comments
Categories genomics
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How Genetic Counselors are Dealing with Direct-to-Consumer Genetic Testing

a genetic counselor talking to a client with DNA in the background

After receiving ancestry information from a direct-to-consumer (DTC) genetic testing company, Ellen Matloff, a certified genetic counselor and frequent writer about the limitations of DTC tests, downloaded her raw data file from their website for interpretation by a third party service. She was shocked to see that her raw data included a variant for Lynch Read More >

Posted on by Suzy Cahn, Guest Blogger, Genetic Counseling Training Program Class of 2019, Emory University School of Medicine and Ridgely Fisk Green, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a comment
Categories genetic counseling, genomics, personal genomics

Introducing “Precision” to the CDC Genomics and Health Impact Update and the Public Health Genomics Knowledge Base

a world map with a GPS, cell phone and DNA and people

For many years, the CDC Office of Public Health Genomics has published the Genomics and Health Impact Weekly Update with the latest information and publications about the real-world impact of genomics on medicine and public health. More recently, we added a second feature to our weekly update, the Advanced Molecular Detection (AMD) Clips, highlighting the Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention.Leave a comment
Categories genomics, precision public health
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Public Health Genomics: What’s Next?

a figure looking at a sign labeled Public Health Genomics with an arrow going to another sign labeled Precision Public Health and a double helix in the background

In the 1990’s, the excitement surrounding the Human Genome Project led the public health community to plan for the future role of genomics in health care and disease prevention. The field of public health genomics was launched to identify opportunities for the new science to impact health, inform public health programs and health care providers Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment
Categories genomics

Let’s not get too excited about genome sequencing of healthy newborns. Here’s why!

Newborn screening (NBS) is the largest public health genetics program around the world.  Each year in the United States, thousands of babies are saved from lifelong disability and death by timely diagnosis and treatment. While most newborns are screened with biochemical tests that use drops of blood from a heel prick, new advances in genome Read More >

Posted on by Scott D. Grosse, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, Jeffrey R. Botkin, University of Utah, Salt Lake City, Utah, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia1 Comment
Categories genomics, newborn screening

Preventive medicine can be more precise and precision medicine can be more preventive!

a person being magnified in a crowd with a magnifying glass and a doctor holding a stethoscope on the crowd with DNA

In a recent JAMA viewpoint, Psaty and coauthors compare precision medicine and preventive medicine as two distinct models in medicine and public health. They use the example of hemophilia B to illustrate how new gene therapy can successfully target treatment with high specific-activity factor IX variant. They contrast this model of precision medicine with the Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 Comment
Categories genomics, precision medicine, prevention

Your Top 10 Public Health Genomics Knowledge Base Searches in 2018!

Top 10 2018 on building blocks

Genetic counseling, Alzheimer’s disease, and personal genomics top the list. Top 2018 PHGKB Search Terms Genetic counseling Alzheimer’s disease Personal Genomics Autism Disparities Nutrigenomics Familial Hypercholesterolemia Precision Public Health Precision Medicine Rare Diseases Recently, USA Today revealed 2018’s most popular Google search terms with (the) “World Cup” topping the list. Aptly named, the event, taking Read More >

Posted on by Scott Bowen and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment
Categories genomics

Implementing Genomics-Based Screening Programs for Healthy Adults: A Proposed Evidence-based Approach from the Genomics and Population Health Action Collaborative

A Proposed Approach for Implementing Genomics-Based Screening Programs for Healthy Adults - A National Academy of Medicine Discussion Paper nam.edu/Perspectives with an image of DNA

The following report was developed by the Genomics and Population Health Action Collaborative (GPHAC) as a potential roadmap for groups planning to carry out projects involving genomics-based screening programs in the healthy adult populations. The report is available in its entirety on the National Academy of Science, Engineering and Medicine website. The advent of next Read More >

Posted on by Muin J. Khoury and W. David Dotson, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment
Categories genomics, Population screening, screening
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Happy Thanksgiving 2018: Protect your family’s health by using My Family Health Portrait to collect and share your family health history

a multigenerational familly eating a thanksgiving meal and a picture of DNA is hanging on the wall

Happy Thanksgiving Day! It is time to send our yearly message on the importance of family health history to your own health. Every year we emphasize a slightly different version of this message. In 2017, we highlighted the simple fact that even in the age of genomics and precision medicine, family health history remains as Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a comment
Categories family history, genomics
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