Category: birth defects

Using Pharmacogenomics to Better Understand the Role of Selected Medications and Birth Defect Risk

DNA encased in a pill with a pregnant woman

Through a funding opportunity from CDC’s Office of Genomics and Precision Public Health in collaboration with the Office of Advanced Molecular Detection, CDC’s Birth Defects Monitoring and Research Branch in the National Center on Birth Defects and Developmental Disabilities will conduct a 2-year project to gather genome-wide genotyping data to look at relationships between pharmacogenomic Read More >

Posted on by Mary Jenkins, Lynn Almli, Jennita Reefhuis. Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia
Categories genomics, pharmacogenomics
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Genome-wide Association studies (GWAS) in the Quest to Understand the Causes of Birth Defects

a woman and doctor looking at a newborn with a Manhatten plot on the background

Our recent review and commentary found that relatively few genome-wide association studies (GWAS) on structural birth defects have been done, compared with the number of GWAS on other conditions. We reviewed the literature to identify GWAS on oral clefts, congenital heart defects (CHDs), biliary atresia, pyloric stenosis, hypospadias, craniosynostosis, and clubfoot. We did not find Read More >

Posted on by Ridgely Fisk Green, Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention; Philip J. Lupo, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine; Laura E. Mitchell, Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health; Mary M. Jenkins, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention
Categories genomics
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