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Can a Healthy Lifestyle Reduce Your Risk of Dementia Regardless of Your Genes?
A large retrospective, cohort study found that a healthy lifestyle is associated with a lower risk for dementia among people considered at high genetic risk. An active lifestyle, which includes a nutritious diet, limited alcohol, and not smoking, has long been associated with reduced risk of cancer and heart disease. In the last ten years,
Posted on byThe use of polygenic risk scores in clinical practice can exacerbate health disparities in ethnic and minority populations
This blog is a summary of our recent commentary on polygenic risk scores (PRS). PRS provide a rapidly emerging example of precision medicine and are based on multiple gene variants that each have weak associations with disease risks, but collectively may enhance disease predictive value in the population. The added value of PRS is unclear
Posted on by 1 CommentIs it Time to Integrate Polygenic Risk Scores into Clinical Practice? Let’s Do the Science First and Follow the Evidence Wherever it Takes Us!
In case you have not been paying much attention to genomic medicine research or social media coverage, you might have missed a clear uptick in the past couple of years on the value of polygenic risk scores in clinical practice and population screening. (see examples here, here, here, and here) Polygenic risk scores (PRS) summarize
Posted on by 1 CommentResearch on the Behavioral Impact of Polygenic Risk Scores: The Train Has Already Left the Station!
There has been a lot of discussion recently about the new generation of polygenic risk scores (information about a person’s disease risk based on many dozens, hundreds, thousands, or even millions of common DNA variants in their genome), and whether these new-and-improved genetic risk scores are going to turn out to be useful for disease
Posted on byIntroducing the Rare Diseases Genomics and Precision Health Knowledge Base
For the past three years, The CDC Public Health Genomics Knowledge Base (PHGKB) has been tracking the public health impact of advances in genomics and precision technologies. Every day, we provide new information and publications for researchers, health care providers, policy makers, and the general public. We also offer access to the latest epidemiologic and
Posted on by 2 CommentsHow Genetic Counselors are Dealing with Direct-to-Consumer Genetic Testing
After receiving ancestry information from a direct-to-consumer (DTC) genetic testing company, Ellen Matloff, a certified genetic counselor and frequent writer about the limitations of DTC tests, downloaded her raw data file from their website for interpretation by a third party service. She was shocked to see that her raw data included a variant for Lynch
Posted on byPublic Health Genomics: What’s Next?
In the 1990’s, the excitement surrounding the Human Genome Project led the public health community to plan for the future role of genomics in health care and disease prevention. The field of public health genomics was launched to identify opportunities for the new science to impact health, inform public health programs and health care providers
Posted on byPreventive medicine can be more precise and precision medicine can be more preventive!
In a recent JAMA viewpoint, Psaty and coauthors compare precision medicine and preventive medicine as two distinct models in medicine and public health. They use the example of hemophilia B to illustrate how new gene therapy can successfully target treatment with high specific-activity factor IX variant. They contrast this model of precision medicine with the
Posted on by 1 CommentSatisfying Popular Curiosity: What Is Genetic Counseling?
As 2018 comes to a close and the data comes rolling in, it can officially be said that “genetic counseling” was the most popular search term in the Public Health Genomics Knowledge Base (PHGKB). Genetic counseling is one of the fastest growing careers in the country, with a growth rate of 29% since 2016, according
Posted on byHappy Thanksgiving 2018: Protect your family’s health by using My Family Health Portrait to collect and share your family health history
Happy Thanksgiving Day! It is time to send our yearly message on the importance of family health history to your own health. Every year we emphasize a slightly different version of this message. In 2017, we highlighted the simple fact that even in the age of genomics and precision medicine, family health history remains as
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