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10 results for colorectal cancer

Beyond Base Pairs to Bedside: A Community Consultation on Closing the Gap between Genomic Discoveries and the Public’s Health

Priorities for Public Health Genomics 2012-2017

In June 2011, the CDC Office of Public Health Genomics launched a community wide consultation process to develop priorities for the field of public health genomics in the next 5 years. This process was initiated as part of strategic visioning for integrating the emerging tools of genomics into practice and assuring the success of these

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , ,

Can We have Our Genome and Eat It Too? Deploying the Whole Genome Sequence In Medicine and Public Health, One Base Pair At A Time.

cake with double helix decoration - text: One base pair at a time

This post was originally published November 3, 2011 but is still very much applicable in 2013! The popular proverbial saying “you cannot have your cake and eat it too”  implies that one cannot consume something and preserve it at the same time–in other words, we cannot have it both ways.  Well, for once, maybe we

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention4 Comments

Feeling the Genomic Pulse of the United States

CDC doctor with DNA stethoscope checking the pulse of the US map

A healthcare provider takes a good clinical history, feels the patient’s pulse, performs a good physical examination, and orders laboratory tests to diagnose and manage a health problem. In a similar manner, public health programs feel the pulse of the population by collecting data through population surveys, surveillance systems and health statistics to assess the

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention3 CommentsTags ,

The Promise of Population-based Genomic Screening for Selected Hereditary Conditions: Contributions of Cost-Effectiveness Analysis

individuals connected with DNA and dollar bills in the background

It is estimated that 3 million people in the United States carry pathogenic variants that increase their risks for heart disease and cancer. If people with such variants are identified, medical interventions are available to significantly reduce morbidity and mortality. However, existing recommendations tend to emphasize family-based or ethnic-specific criteria to determine at-risk individuals for

Posted on by Nandana D. Rao, Lu Shi, Muin J. Khoury, Office of Genomics and Precision Public Health, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia1 CommentTags ,

Population-based Genomic Screening Programs: The Need for Optimal Implementation to Ensure Health Equity

a crowd, a hand holding DNA sequence, three diverse people, and a double helix

Population genomic screening of adults has emerged as a strategy to promote prevention of common diseases such as cancer and heart disease among persons with genetic conditions. This type of screening has the potential to identify millions of currently undetected people in the United States who are at risk of preventable diseases for which evidence-based

Posted on by Nandana D. Rao, W. David Dotson, Muin J. Khoury, Office of Genomics and Precision Public Health, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Population Screening for Rare Pathogenic Variants as the Low Hanging Fruit for Public Health Genomics Across the Lifespan

a family with a tree of DNA with low hanging circles of people and many different hands reaching to them

Rapid advances in human genome sequencing technologies have accelerated the integration of genomics into clinical practice. Genomics has demonstrated clinical utility as a diagnostic tool for certain diseases, but its potential for population screening is still work in progress. In principle, DNA-based population screening can identify persons with rare pathogenic variants who are at high

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia1 CommentTags

The Use of Cell-free DNA in Clinical Practice: Work in Progress

DNA in test tubes and a doctor with a stethoscope

A recent review outlines the use of circulating tumor DNA (ctDNA) in clinical practice and the requirements necessary to extend the use of this technology for health impact. Cell-free DNA (cfDNA) is extracellular strands of DNA present in body fluids. Circulating tumor DNA (ctDNA) is a specific type of cfDNA that originates from a primary tumor, circulating

Posted on by Mindy Clyne, Katherine Kolor, Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Polygenic Risk Scores in Clinical Practice? Still Making the Case

a polygenic risk score curve with a double helix, a doctor pointing at a tablet with icons surround it, and a doctor talking to her patient

Two recent systematic reviews show the lack of data on clinical utility of polygenic risk scores and major challenges in implementation. The Promise of Polygenic Risk Scores in Population Health Many common diseases such as cancer, diabetes, and heart disease, result from the combination of genetic factors and physical and social environmental factors. Genome-wide association

Posted on by Jeffery Osei, Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia; W. David Dotson, Marta Gwinn, Ridgely Fisk Green, Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta GeorgiaLeave a commentTags , ,

Public Health Genomics Priorities Through a Health Equity Lens

three individuals with one having a magnifying glass on him with a double helix

Achieving Health Equity in Genomics and Precision Medicine is More Important than Ever The CDC Office of Genomics and Precision Public Health is undergoing strategic planning to identify priorities and actions for genomics and precision medicine. As we embark on this work, we are focusing on health equity. The potential for genomics and precision medicine

Posted on by Muin J. Khoury, Scott Bowen, David Dotson, and Katherine Kolor, Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Personal Reflections on Genomics, Health Equity, and Public Health

My nephew, Eddie, and niece, Sheri, were lively, witty, high-spirited, active, bright, and full of hope. Eddie dreamed of becoming a professional baseball player, while Sheri aspired to become a mathematical engineer. But their childhood diagnoses with a type of kidney disease called nephrotic syndrome ended those dreams. While nephrotic syndrome can be inherited, we

Posted on by Michelle Rose, Office of Science Scientific Rotation 2020–2021 cohort, and Ridgely Fisk Green, Office of Genomics and Precision Public HealthLeave a commentTags