Category: genomics
Introducing the CDC Tier-Classified Guidelines Database
Over the last several years, OPHG has hosted a “Tier Table” database of genomic applications (i.e., clinical scenarios involving genomic testing) sorted into one of three tiers using a method described in Clinical Pharmacology and Therapeutics, 2014. The purpose of creating the database was to help organize evidence (such as recommendation statements contained in guidelines, Read More >
Posted on byFrequently Asked Questions about the CDC Tier-Classified Guidelines Database
Over the last several years, OPHG has hosted a “Tier Table” database of genomic applications (i.e., clinical scenarios involving genomic testing) sorted into one of three tiers using a method described in Clinical Pharmacology and Therapeutics, 2014. The Tier Table is being replaced with our new Tier-Classified Guidelines Database, which we hope will promote more Read More >
Posted on byIs it Time to Integrate Polygenic Risk Scores into Clinical Practice? Let’s Do the Science First and Follow the Evidence Wherever it Takes Us!
In case you have not been paying much attention to genomic medicine research or social media coverage, you might have missed a clear uptick in the past couple of years on the value of polygenic risk scores in clinical practice and population screening. (see examples here, here, here, and here) Polygenic risk scores (PRS) summarize Read More >
Posted on by 1 CommentCan Predictive Analytics Drive Implementation Research to Improve Population Health?
To date, research investments have yielded many highly effective health interventions for disease prevention and treatment. Examples include smoking cessation, lipid and blood pressure control as well as diet and physical activity interventions. Yet, many interventions are not being optimally delivered to have public health impact. Implementation research can provide a means to determine optimal Read More >
Posted on byLack of Knowledge of Natural History of New Biomarkers: The Achilles’ Heel of Precision Health!
In Greek mythology, when Achilles was a baby, it was foretold that he would die young. To prevent his death, his mother dipped his body in the River Styx, which was supposed to offer powers of invulnerability. However, as she held the baby by the heel, the heel did not come into contact with the Read More >
Posted on byTime to Keep a Smart Watch on Precision Health
A Science-Based Vision for the Wearable Revolution It is 2022, Juan, 45 years old, is thrilled to purchase a new smartwatch he can afford because it is offered at a discount through a special program with his employer. Juan plans to track his physical activity, heart rate, diet, and sleep. Under the program, Juan also Read More >
Posted on by 2 CommentsResearch on the Behavioral Impact of Polygenic Risk Scores: The Train Has Already Left the Station!
There has been a lot of discussion recently about the new generation of polygenic risk scores (information about a person’s disease risk based on many dozens, hundreds, thousands, or even millions of common DNA variants in their genome), and whether these new-and-improved genetic risk scores are going to turn out to be useful for disease Read More >
Posted on byIntroducing the Rare Diseases Genomics and Precision Health Knowledge Base
For the past three years, The CDC Public Health Genomics Knowledge Base (PHGKB) has been tracking the public health impact of advances in genomics and precision technologies. Every day, we provide new information and publications for researchers, health care providers, policy makers, and the general public. We also offer access to the latest epidemiologic and Read More >
Posted on by 2 CommentsHow Genetic Counselors are Dealing with Direct-to-Consumer Genetic Testing
After receiving ancestry information from a direct-to-consumer (DTC) genetic testing company, Ellen Matloff, a certified genetic counselor and frequent writer about the limitations of DTC tests, downloaded her raw data file from their website for interpretation by a third party service. She was shocked to see that her raw data included a variant for Lynch Read More >
Posted on byIntroducing “Precision” to the CDC Genomics and Health Impact Update and the Public Health Genomics Knowledge Base
For many years, the CDC Office of Public Health Genomics has published the Genomics and Health Impact Weekly Update with the latest information and publications about the real-world impact of genomics on medicine and public health. More recently, we added a second feature to our weekly update, the Advanced Molecular Detection (AMD) Clips, highlighting the Read More >
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