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Happy Holidays! Celebrating the Arrival of 2018 and 20 Years of Public Health Genomics!
This December, we are especially excited as we anticipate the dawning of a bright new year. The ebbing of 2017 marks the end of, not just another year, but two decades of public health genomics. Recently we were provided two valuable opportunities to place a capstone on this important milestone. Last month, at the American
Posted on byPublic health genomics information is now easily accessible online
The amount of emerging genomic information related to healthcare and public health is staggering. PHGKB is a one-stop shop for information relevant to genomics translation and population health impact for almost all diseases across the life span. MyPHGKB allows end users to customize their own PHGKB databases and type of information. The Public Health Genomics
Posted on byThe Cancer Moonshot, Hereditary Cancers and Population Genetic Screening
In September 2016, the Cancer Moonshot Blue Ribbon Panel delivered a report with 10 ambitious recommendations to shape cancer research for the next five years. One recommendation is to “expand use of proven prevention and early detection strategies.” [PDF 199 KB] There is a lot we can do to prevent cancer now— even with no
Posted on byThe Success of Precision Medicine Requires a Public Health Perspective
The announcement of a new major US Precision Medicine initiative comes more than a decade after the completion of the Human Genome Project, the ambitious project that culminated in sequencing all 3 billion base pairs of our genome. Continuous improvement in the quality of sequencing, dramatic reduction in price, and ongoing advances in multiple sectors
Posted on by 1 CommentWhy We Can’t Wait: A Public Health Approach to Health Disparities in Genomic Medicine
In May 2013, I attended and presented at the “Why We Can’t Wait Conference to Eliminate Health Disparities in Genomic Medicine.” The conference was organized by the University of Miami and Stanford University, with attendees and speakers from academia, consumer organizations, government agencies, public health, clinical practice, and the private sector. A key rationale for
Posted on byCost-effectiveness of Pharmacogenomic Testing: How to Measure the Value of Having the Right Dose of the Right Drug for the Right Patient
A recent systematic review that assessed the cost-effectiveness of pharmacogenetic testing for drugs with existing guidelines concluded that most studies favored pharmacogenomic testing. The significance of this conclusion must be interpreted with caution and in the context of study factors, such as funding sources, geography, cohort, and the cost-effectiveness comparisons being made. Pharmacogenomics (PGx) combines
Posted on byPopulation Screening for Rare Pathogenic Variants as the Low Hanging Fruit for Public Health Genomics Across the Lifespan
Rapid advances in human genome sequencing technologies have accelerated the integration of genomics into clinical practice. Genomics has demonstrated clinical utility as a diagnostic tool for certain diseases, but its potential for population screening is still work in progress. In principle, DNA-based population screening can identify persons with rare pathogenic variants who are at high
Posted on by 1 CommentIncreasing Use and Impact of Family Health History in Medically Underserved Populations: Work in Progress
Despite years of public health efforts, family health history remains underutilized in clinical care, especially among people who are medically underserved. To address these issues, CDC’s Office of Genomics and Precision Public Health hosted a webinar on November 14, 2022, in conjunction with National Family Health History Day (Thanksgiving). The speakers called for better informed,
Posted on byPublic Health Genomics at the Centers for Disease Control and Prevention: Happy 25th Anniversary!
In 1997, in response to the Human Genome Project, the CDC formed the Office of Genetics and Disease Prevention, now called the Office of Genomics and Precision Public Health (OGPPH). This was the beginning of the public health genomics movement in the United States and around the world. Our office continues to serve CDC programs,
Posted on by 1 CommentGenomics, Health Equity, and Global Health
The World Health Organization’s Science Council recently issued its first report on accelerating access to genomics for global health. The report makes a strong case for less-resourced countries to gain access to such technologies. Although remarkable progress has been made in the translation of genomic discoveries into health benefits, in 2020, the World Health Organization (WHO) reminded
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