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1-BP: A Potential Occupational Hazard

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1-bromopropane text written over a circleIn recent years we have seen an increase in the use of the solvent 1-bromopropane (1-BP) as a substitute for ozone-depleting chlorofluorocarbons and other regulated compounds. 1-BP is used in multiple manufacturing processes, including vapor and immersion degreasing operations to clean electronics and metal and as a solvent vehicle in industries using aerosol applied adhesives such as foam cushion manufacturing. In some states, 1-BP is now being used as an alternative solvent within the dry cleaning industry in response to the restricted use of perchloroethylene, which is considered “probably carcinogenic to humans” by the International Agency for Research on Cancer (IARC).

The toxic nature of 1-BP is not fully understood. Case reports demonstrating neurotoxic, reproductive, development and other health effects in workers who use or make 1-BP indicate that the brominated solvent may represent an unrecognized occupational health risk. In this week’s issue of the Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report, the National Institute for Occupational Safety and Health (NIOSH) presents two independent cases of 1-BP exposed workers diagnosed with the clinical manifestations of neurotoxicity. These cases from the electronics and dry cleaning industries, when coupled with previously reported studies of workers exposed to 1-BP in the foam cushion manufacturing industry, illustrate the potential health risk of 1-BP exposures.

Limited exposure and human health effect data are currently available concerning 1-BP, but the National Toxicology Program (NTP) has concluded that there is sufficient evidence of developmental and reproductive toxicity among animals exposed to 1-BP. NIOSH is in the process of evaluating exposures and potential health effects among workers potentially exposed to 1-BP. Additionally, NIOSH is working with a major manufacturer of 1-BP products to better understand their extent of use, proper methods for handling the material, and practices that will minimize worker exposure.

Currently, NIOSH does not have a Recommended Exposure Limit (REL), nor does the Occupational Safety and Health Administration (OSHA) have a Permissible Exposure Limit (PEL) for 1-BP. The American Conference of Governmental Industrial Hygienists (ACGIH) recommends an 8-hour time weighted average (TLV) of 10 parts per million (ppm) to provide protection against the potential for neurotoxicity, hepatotoxicity, and reproductive and developmental toxicity in 1-BP exposed workers. Other professional organizations and manufacturers have recommended exposure limits ranging from 20 to 100 ppm. The U.S. Environmental Protection Agency stated in May 2007 that exposures within or below the range of 17 to 30 ppm are anticipated to be protective against reproductive effects in men and women.

As we work to better understand the possible risks associated with workplace exposure to 1-BP, NIOSH recommends engineering controls and work practices to limit workers exposures within facilities where 1-BP is manufactured, used, handled, or stored. Substitution, engineering controls, administrative controls, and lastly, personal protective equipment can help reduce or eliminate exposure.

Through this blog and the MMWR article we hope to alert employers, clinicians, and public health professionals to potential health effects among workers exposed to 1-BP, particularly in workplaces where 1-BP use may be increasing (such as in drycleaning and solvent cleaning) and to emphasize the need for effective control methods to limit worker exposure to 1-BP.

—G. Scott Dotson, Ph.D., and Charles L. Geraci, Ph.D., CIH

Dr. Dotson is an Industrial Hygienist in the NIOSH Education and Information Division. Dr. Geraci is a Supervisory Physical Scientist and Chief of the Document Development Branch in the NIOSH Education and Information Division.

Posted 12/8/08 at 3:30 pm

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5 comments on “1-BP: A Potential Occupational Hazard”

Comments listed below are posted by individuals not associated with CDC, unless otherwise stated. These comments do not represent the official views of CDC, and CDC does not guarantee that any information posted by individuals on this site is correct, and disclaims any liability for any loss or damage resulting from reliance on any such information. Read more about our comment policy ».

    It is distressing to learn that when substituting an apparently “safer” alternative to perchlroethylene in the dry cleaning industry, we may have created a new clinical problem. How can we inform workers in this industry about the potential harmful effects of 1-BP and ways to reduce or eliminate risk?

    The MMWR and blog were created to raise awareness about the potential hazards of 1-BP. NIOSH is working on a Current Intelligence Bulletin (CIB) on 1-BP. We also plan to create additional materials written for a more general audience. In the mean time, we encourage the sharing and circulation of the information in the blog and the MMWR.

    NIOSH initially investigated the hazards of occupational exposure to 1-BP within a series of Health Hazard Evaluations (HHEs). The HHEs assessed the use of 1-BP within vapor degreasing operations in an electronics cleaning facility and as a solvent vehicle within the application of spray adhesives during foam cushion manufacturing. The following links contain the results of these studies.

    1. http://www.cdc.gov/niosh/hhe/reports/pdfs/2000-0233-2845.pdf
    2. http://www.cdc.gov/niosh/hhe/reports/pdfs/1999-0260-2906.pdf
    3. http://www.cdc.gov/niosh/hhe/reports/pdfs/2000-0410-2891.pdf
    4. http://www.cdc.gov/niosh/hhe/reports/pdfs/1998-0153-2883.pdf

    1-Bromopropane can harm both the nervous system and the reproductive system. It can damage the nervous system by interfering with nerve conduction, resulting in limb weakness, pain, numbness, and paralysis. It can cause reduced fertility and/or sterility in test animals, both male and female, and it can harm the developing fetus in pregnant female test animals. It will soon be tested to find out if it can cause cancer, as many similar chemicals do. Other harmful effects include irritation of the eyes and skin.

    On December 17, 2009, the California Occupational Safety and Health Standards Board (OSHSB) voted to adopt a 5 ppm Permissible Exposure Limit [8-hour, time-weighted average] for 1-BP. Further information can be obtained from the OSHSB website:

    http://www.dir.ca.gov/oshsb/oshsb.html

    A core component of the new wave of chemical risk management (REACH, Green job OSHA mandates, etc…)is that of selecting alternate “safer” chemicals to replace those with documented adverse health and environmental effects.

    I am interested in knowing the process by which 1-BP was deemed a suitable, “non-toxic” replacement to perchlroethylene.

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