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Category: evidence-based medicine

Celebrating a Decade of Evidence-Based Evaluation of Genomic Tests

Ira Lubin, Doris Zallen, Dave Dotson, Sheri Schully, Marc Williams, Ned Calonge, Roger Klein, Muin Khoury and Cecile Janssens at the EGAPP meeting

CDC’s Office of Public Health Genomics (OPHG) launched the Evaluation of Genomic Applications in Practice and Prevention Initiative (EGAPP) in 2004. The independent EGAPP Working Group (EWG) celebrated a decade of achievements and accomplishments at their meeting in Atlanta on October 27-28, 2014. The EWG is comprised entirely of volunteers, encompassing multiples areas of expertise Read More >

Posted on by W. David Dotson and Muin J Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , , ,

Public Health Approach to Big Data in the Age of Genomics: How Can we Separate Signal from Noise?

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The term Big Data is used to describe massive volumes of both structured and unstructured data that is so large and complex it is difficult to process and analyze. Examples of big data include the following: diagnostic medical imaging, DNA sequencing and other molecular technologies, environmental exposures, behavioral factors, financial transactions, geographic information & social Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 CommentTags ,

Is Evidence-based Medicine the Enemy of Genomic Medicine?

hands pulling on DNA with DNA in background

A general practitioner recently writing in the BMJ,  said that evidence-based medicine is polluted with “fraud, sham diagnosis, short term data, poor regulation, surrogate ends, questionnaires that can’t be validated, and statistically significant but clinically irrelevant outcomes”, all leading to “overdiagnosis and misery”. In more temperate tones, Goldberger and Buxton recently suggested  in a JAMA Read More >

Posted on by Alison Stewart and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags ,

New Products from the EGAPP Working Group: Further Development of Evidence Review Methodology and More Recommendations in Genomic Medicine

EGAPP logo

The independent EGAPP working group (EWG) held its 27th meeting on May 13-14, 2013 via a virtual online venue. The EWG has been very active since the last meeting.  Highlights included: The EWG has four new publications since the last meeting: Recommendations from the EGAPP Working Group: does genomic profiling to assess type 2 diabetes Read More >

Posted on by Michael P. Douglas and W. David Dotson, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , ,

Implementing Evidence-based Genomics Recommendations at the Intersection of Public Health and Healthcare

several publications from Michigan

We take the opportunity of March 22, 2013, designated as Lynch Syndrome Awareness Day by 13 U.S. state governors and counting, to highlight state public health genomics programs that are taking innovative approaches to implement evidence-based genomic testing recommendations for hereditary cancer syndromes, including Lynch syndrome.  Read More >

Posted on by Jenna McLosky and Debra Duquette, Michigan Department of Community Health Beverly Burke and Joan Foland, Connecticut Department of Public HealthLeave a commentTags , ,

Accelerating the Development of Evidence Reviews and Recommendations in Genomic Medicine

EGAPP logo

The independent EGAPP working group (EWG) held its 26th meeting on February 11-12, 2013 at the CDC campus in Atlanta. Highlights included: Three EWG recommendation statements on the validity and utility of genetic tests are pending publication on: KRAS, BRAF and other markers involved in EGFR signaling, which are used to inform choice of therapies for Read More >

Posted on by Michael P. Douglas and W. David Dotson, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , , ,

New Strategies For Public Health Genomics Beyond Newborn Screening

Opening speaker, Dr. Ursula Bauer Director, NCCDPHP discusses a point later in the day with Dr. Khoury, OPHG Director

A Working Meeting and an Action Plan to Save Lives Now Nearly 2 million Americans are affected by one of three genetic conditions with a strong risk of early morbidity and mortality: BRCA 1/2 and hereditary breast and ovarian cancer; Lynch syndrome and colorectal , endometrial and ovarian cancer; and familial hypercholesterolemia and early cardiovascular events.  At Read More >

Posted on by Scott Bowen and Karen Greendale, Office of Public Health Genomics, Centers For Disease Control and Prevention2 CommentsTags , , ,

Evidence Matters in Genomic Medicine—Round 3: Integrating Family Health History into Clinical Preventive Services

stacked boxes with pedigree

A new podcast from the CDC Expert Commentary Series on Medscape—Family Health History: Use It to Inform Preventive Services for Your Patients— describes how family health history can inform the delivery of preventive health services.   The podcast presents three case studies based on recommendations of the US Preventive Services Task Force (USPSTF):  screening for lipid Read More >

Posted on by Katherine Kolor and Muin J Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , , , ,

More Workings of an Evidence-Based Genomic Panel: Modernizing the Evidence Review Process

EGAPP logo

The independent EGAPP working group (EWG) held its 25th meeting on September 10-11, 2012 at the CDC campus in Atlanta. Highlights included: Three EWG recommendation statements on the validity and utility of genetic tests are pending publication on: KRAS, BRAF and other markers involved in EGFR signaling, which are used to inform choice of therapies for Read More >

Posted on by W. David Dotson and Michael P. Douglas, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags ,

Evidence Matters in Genomic Medicine- Round 2: Integrating Cancer Genomic Tests

stacked boxes with lettering

  In a previous blog, CDC’s Office of Public Health Genomics announced a list of health-related genomic tests and applications, stratified into three tiers according to the availability of scientific evidence and evidence-based recommendations as a result of systematic reviews.  The list is intended to promote information exchange and dialogue among researchers, providers, policy makers, and Read More >

Posted on by Michael P. Douglas and W. David Dotson, Office of Public Health Genomics, Centers for Disease Control and Prevention1 CommentTags , , ,
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