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W. Charles Huskins, MD, MSc is a Consultant in Pediatric Infectious Diseases at Mayo Clinic and an Assistant Professor of Pediatrics in the College of Medicine, Mayo Clinic. Dr. Huskins led the Strategies to Reduce Transmission of Antimicrobial Resistant Bacteria in Intensive Care Units (STAR*ICU) trial, a study funded by the National Institute of Allergy and Infectious Diseases and conducted through the Bacteriology and Mycology Study Group. The STAR*ICU trial was a multicenter, cluster (ICU)-randomized trial of the effectiveness of culture-based active surveillance and expanded use of barrier precautions in reducing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) in adult ICUs.